This is a gross display of professional negligence.
You assured your readers this DNA remains In The cytosol, yet any of your readers who have actually read our paper on the topic will have understood Dean et al which demonstrates the SV40 promoter has a nuclear targeting sequence which localizes to the nucleus in hours in all cell lines studied to date.
You also omitted any discussion of Drayman et al demonstrating the SV40 promoter sequence in the vaccine binds to the tumor suppressor gene p53. There are billions of copies of these in every dose. You deflect your your readers with billions of gram of DNA without discussing copy number of these DNAs? 10-100 billion copies of these SV40 promoters in every dose given.
You yourself stopped taking these jabs but continue to defend their use with illusions and misdirections like your article above.
Your readers would be wise to scrutinize your conflicts of interest in this field. They would get a more informed opinion with an AI chatbot.
AI isn’t going to take the blue collar jobs. It’s going wipe out the parasitic crony class first and you are clearly its first victim.
Dr Offit, you didn’t mention that the DNA is not naked - but rather, packaged in LNPs.
Could you also address the role of the SV40 promoter in the Pfizer contamination, which is known to be good at dragging contents into the cell nucleus?
Dr Malone is a serious doctor top of his field. There are many doctors in emergency, heart, and cancer tracking the after math of the COVID vaccine which was not properly tested and has caused immeasurable vaccine injury to too many. Here is an interview I did with Canadian emergency doctor who has sacrificed everything to tell the truth. https://rumble.com/v412nvl-putting-everything-on-the-line-to-fight-for-people-exclusive-w-dr.-trozzi-s.html
You cannot silence everyone with your snarky smear attacks on doctors and politicians willing to expose the truth.
Dr. Offit. There are a number of errors and omissions in your post.
The omissions: You omitted the important fact that the plasmids also contain code for SV-40 promoters and enhancers.
The errors. 1. As documented by Dr. Kevin McKernan, there are very significant amounts of DNA contamination in the vaccine vials. You keep referring to them as "small quantities of DNA" and "trace amounts of DNA", which are "cpmpletely and utterly harmless".
2. You say the excess DNA was filtered out in the process of making the RNA to be included in the vaccines. Again, refer to Kevin McKernan's work. He sequenced the vials and found DNA in abundance,
3. You claim "It is virtually impossible for foreign DNA to enter the nucleus of a cell that is not dividing" Even when there are SV-40 promoters and enhancers in the mix? Numerous papers contradict you on this.
You have not responded to my debate challenge re: the origin of SARS-2 (you claim it got into the human population through natural zoonotic spillover) and your claim that 1.2 million people died in the US from Covid.
Regarding the snarky character assassination repeatedly practiced by Dr. Offit and directed towards myself, who he has never met and apparently also never reviewed my actual CV, these are the words and strategies of a propagandist, not a serious academic full professor and endowed chair. I am constantly amazed that CHOP tolerates his lack of professionalism.
A general observation for those just digging into this thread.
There are people on this thread that have their reputation at stake.
There others having a complete meltdown tossing anti-vax slurs around who are anonymous and demanding/challenging the credentials of those non-anon scientists raising concerns. This asymmetry should not go unnoticed.
Choose wisely who you listen to as those with zero reputational risk pay no price for being wrong.
You will note that despite over 250 comments on this thread from the scientists that Paul Offit ridicules, Paul Offit has yet to step into the conversation to defend his work.
Dr. Paul Offit behaves and communicates like a vaccine industry propagandist, not like a serious academic endowed full professor. His repeated snarky character assassination should alert his Dean to his lack of professional decorum on social media. Why is this person relied upon by FDA and CDC? https://pauloffit.substack.com/p/vaccine-safetyby-marjorie-taylor-b36
I would note Dr Malone's positions are well supported with data, facts, studies and are echoed and supported by fellow experts around the world. Analyses demonstrate increased all cause mortality when "vaccines" were deployed. More importantly it is now well established that early treatment with affordable and effective repurposed drugs would have saved lives and avoided enormous physical and economic harms. That this was not immediately and exclusively pursued damns the Public Health actions! What US and other world governments instead delivered has been gaslighting, psyops, physical harms, deaths and devastation. Maybe it would be helpful for you to go back and further review the outcomes of the Government directed 'solutions '
Dr. Offit is quite aged, and has apparently not kept up with modern molecular and cellular biology research. One wonders if, like Dr. Marks, he never did any research involving non-viral gene transfer (transfection). His snarky academic attitude overlooks that many of us have worked in both academia and industry, and in industry one is often focused on publishing patents, not papers.
PATENTS ISSUED:
1. Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response (includes mRNA vaccination). Assigned to Vical, Inc and licensed to Merck. No. 7,250,404, date of issue: 7/31/07. Priority date 3/21/1989.
2. Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected (includes mRNA vaccination).. Assigned to Vical, Inc and licensed to Merck. US Pat. Ser. No. 6,867,195 B1, date of issue: 3/15/05. Priority date 3/21/1989.
3. Generation of an immune response to a pathogen (includes mRNA vaccination). Assigned to Vical, Inc and licensed to Merck. US Pat. Ser. No. 6,710,035, date of issue: 3/23/04. Priority date 3/21/1989.
4. Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human (includes mRNA vaccination). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,673,776, date of issue: 1/6/04. Priority date 3/21/1989.
5. Methods of delivering a physiologically active polypeptide to a mammal (includes mRNA vaccination). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,413,942, date of issue: 7/2/02. Priority date 3/21/1989.
6. Induction of a protective immune response in a mammal by injecting a DNA sequence (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,214,804, date of issue: 4/10/01. Priority date 3/21/1989.
7. DNA vaccines for eliciting a mucosal immune response (includes mRNA). US Pat. Ser. No. 6,110,898, date of issue: 8/29/00. Priority date 1996.
8. Formulations and methods for generating active cytofectin: polynucleotide transfection complexes. US Pat. Ser. No. 5,925,623 7/20/99.
9. Cationic Transport Reagents. US Pat. Ser. No. 5,892,071 issued 4/06/99.
10. Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes. US Pat. Ser. No. 5,824,812 issued 10/20/98.
11. Cationic Transport Reagents. US Pat. Ser. No. 5,744,625 issued 4/28/98.
12. Generation of antibodies through lipid mediated DNA delivery. Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,703,055, date of issue: 12/30/97. Priority date 3/21/1989.
13. Induction of a protective immune response in a mammal by injecting a DNA sequence (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,589,466, date of issue: 12/31/96. Priority date 3/21/1989.
14. Delivery of exogenous DNA sequences in a mammal (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,580,859, date of issue: 12/3/96. Priority date 3/21/1989.
15. Cationic Transport Reagents. US Pat. Ser. No. 5,527,928, date of issue: 6/18/96.
DNA fragments that even the Moderna patent claims are oncogenic are not going to help your very lucrative grift. Soon, this will make your job as a Pharma marketeer much harder than it has been your entire career. Have fun with that.
Perhaps Dr. Offit can spare a few moments to read this? He seems to share the same comprehension deficit as Dr. Marks. And just to be clear, Dr. Offit's seminal work in vaccinology was basically just taking credit for pioneering work of others. Stolen valor.
IF there are only trace amounts of DNA plasmid remaining, perhaps Dr Offit could share with us the QC test results that show only trace amounts? And show us the studies that determine what a safe amount of contamination is?
Because the EMA didn’t seem very happy with the levels of contamination. Though it didn’t stop them letting governments everywhere inject people (despite the documented “you must do better” request) because they’re next to useless.
Dr Offit,
This is a gross display of professional negligence.
You assured your readers this DNA remains In The cytosol, yet any of your readers who have actually read our paper on the topic will have understood Dean et al which demonstrates the SV40 promoter has a nuclear targeting sequence which localizes to the nucleus in hours in all cell lines studied to date.
You also omitted any discussion of Drayman et al demonstrating the SV40 promoter sequence in the vaccine binds to the tumor suppressor gene p53. There are billions of copies of these in every dose. You deflect your your readers with billions of gram of DNA without discussing copy number of these DNAs? 10-100 billion copies of these SV40 promoters in every dose given.
You yourself stopped taking these jabs but continue to defend their use with illusions and misdirections like your article above.
Your readers would be wise to scrutinize your conflicts of interest in this field. They would get a more informed opinion with an AI chatbot.
AI isn’t going to take the blue collar jobs. It’s going wipe out the parasitic crony class first and you are clearly its first victim.
Dr Offit, you didn’t mention that the DNA is not naked - but rather, packaged in LNPs.
Could you also address the role of the SV40 promoter in the Pfizer contamination, which is known to be good at dragging contents into the cell nucleus?
Dr Malone is a serious doctor top of his field. There are many doctors in emergency, heart, and cancer tracking the after math of the COVID vaccine which was not properly tested and has caused immeasurable vaccine injury to too many. Here is an interview I did with Canadian emergency doctor who has sacrificed everything to tell the truth. https://rumble.com/v412nvl-putting-everything-on-the-line-to-fight-for-people-exclusive-w-dr.-trozzi-s.html
You cannot silence everyone with your snarky smear attacks on doctors and politicians willing to expose the truth.
Dr. Offit. There are a number of errors and omissions in your post.
The omissions: You omitted the important fact that the plasmids also contain code for SV-40 promoters and enhancers.
The errors. 1. As documented by Dr. Kevin McKernan, there are very significant amounts of DNA contamination in the vaccine vials. You keep referring to them as "small quantities of DNA" and "trace amounts of DNA", which are "cpmpletely and utterly harmless".
2. You say the excess DNA was filtered out in the process of making the RNA to be included in the vaccines. Again, refer to Kevin McKernan's work. He sequenced the vials and found DNA in abundance,
3. You claim "It is virtually impossible for foreign DNA to enter the nucleus of a cell that is not dividing" Even when there are SV-40 promoters and enhancers in the mix? Numerous papers contradict you on this.
You have not responded to my debate challenge re: the origin of SARS-2 (you claim it got into the human population through natural zoonotic spillover) and your claim that 1.2 million people died in the US from Covid.
Pathetic article Paul Offit.
Alexander Howse and Dr Robert Malone mention Endotoxin in the jabs.
See his paper from 1996 on Endotoxin Contamination of DNA.
https://www.sciencedirect.com/science/article/abs/pii/0168165695000917
You personally actively suppress all measurements of this supertoxin jabbed into the arms of billions.
Regarding the snarky character assassination repeatedly practiced by Dr. Offit and directed towards myself, who he has never met and apparently also never reviewed my actual CV, these are the words and strategies of a propagandist, not a serious academic full professor and endowed chair. I am constantly amazed that CHOP tolerates his lack of professionalism.
A general observation for those just digging into this thread.
There are people on this thread that have their reputation at stake.
There others having a complete meltdown tossing anti-vax slurs around who are anonymous and demanding/challenging the credentials of those non-anon scientists raising concerns. This asymmetry should not go unnoticed.
Choose wisely who you listen to as those with zero reputational risk pay no price for being wrong.
You will note that despite over 250 comments on this thread from the scientists that Paul Offit ridicules, Paul Offit has yet to step into the conversation to defend his work.
Dr. Paul Offit behaves and communicates like a vaccine industry propagandist, not like a serious academic endowed full professor. His repeated snarky character assassination should alert his Dean to his lack of professional decorum on social media. Why is this person relied upon by FDA and CDC? https://pauloffit.substack.com/p/vaccine-safetyby-marjorie-taylor-b36
Courage is contagious. Please find some Dr. Offit.
I would note Dr Malone's positions are well supported with data, facts, studies and are echoed and supported by fellow experts around the world. Analyses demonstrate increased all cause mortality when "vaccines" were deployed. More importantly it is now well established that early treatment with affordable and effective repurposed drugs would have saved lives and avoided enormous physical and economic harms. That this was not immediately and exclusively pursued damns the Public Health actions! What US and other world governments instead delivered has been gaslighting, psyops, physical harms, deaths and devastation. Maybe it would be helpful for you to go back and further review the outcomes of the Government directed 'solutions '
Dr. Offit is quite aged, and has apparently not kept up with modern molecular and cellular biology research. One wonders if, like Dr. Marks, he never did any research involving non-viral gene transfer (transfection). His snarky academic attitude overlooks that many of us have worked in both academia and industry, and in industry one is often focused on publishing patents, not papers.
PATENTS ISSUED:
1. Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response (includes mRNA vaccination). Assigned to Vical, Inc and licensed to Merck. No. 7,250,404, date of issue: 7/31/07. Priority date 3/21/1989.
2. Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected (includes mRNA vaccination).. Assigned to Vical, Inc and licensed to Merck. US Pat. Ser. No. 6,867,195 B1, date of issue: 3/15/05. Priority date 3/21/1989.
3. Generation of an immune response to a pathogen (includes mRNA vaccination). Assigned to Vical, Inc and licensed to Merck. US Pat. Ser. No. 6,710,035, date of issue: 3/23/04. Priority date 3/21/1989.
4. Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human (includes mRNA vaccination). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,673,776, date of issue: 1/6/04. Priority date 3/21/1989.
5. Methods of delivering a physiologically active polypeptide to a mammal (includes mRNA vaccination). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,413,942, date of issue: 7/2/02. Priority date 3/21/1989.
6. Induction of a protective immune response in a mammal by injecting a DNA sequence (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 6,214,804, date of issue: 4/10/01. Priority date 3/21/1989.
7. DNA vaccines for eliciting a mucosal immune response (includes mRNA). US Pat. Ser. No. 6,110,898, date of issue: 8/29/00. Priority date 1996.
8. Formulations and methods for generating active cytofectin: polynucleotide transfection complexes. US Pat. Ser. No. 5,925,623 7/20/99.
9. Cationic Transport Reagents. US Pat. Ser. No. 5,892,071 issued 4/06/99.
10. Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes. US Pat. Ser. No. 5,824,812 issued 10/20/98.
11. Cationic Transport Reagents. US Pat. Ser. No. 5,744,625 issued 4/28/98.
12. Generation of antibodies through lipid mediated DNA delivery. Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,703,055, date of issue: 12/30/97. Priority date 3/21/1989.
13. Induction of a protective immune response in a mammal by injecting a DNA sequence (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,589,466, date of issue: 12/31/96. Priority date 3/21/1989.
14. Delivery of exogenous DNA sequences in a mammal (includes mRNA). Assigned to Vical, Inc, licensed to Merck. US Pat. Ser. No. 5,580,859, date of issue: 12/3/96. Priority date 3/21/1989.
15. Cationic Transport Reagents. US Pat. Ser. No. 5,527,928, date of issue: 6/18/96.
One of your worst nightmares is about to become painfully real.
Independent labs across the world are measuring Endotoxin in the jabs.
Hang your head in shame.
https://geoffpain.substack.com/p/measuring-endotoxin-in-jabs-with
DNA fragments that even the Moderna patent claims are oncogenic are not going to help your very lucrative grift. Soon, this will make your job as a Pharma marketeer much harder than it has been your entire career. Have fun with that.
Perhaps Dr. Offit can spare a few moments to read this? He seems to share the same comprehension deficit as Dr. Marks. And just to be clear, Dr. Offit's seminal work in vaccinology was basically just taking credit for pioneering work of others. Stolen valor.
https://brownstone.org/articles/fda-fails-to-address-dna-adulteration-concerns/
Perhaps the notoriously condescending Dr. Offit could respond to this? It is only a 10 minute hit, with transcript. It should not take him very long.
https://rwmalonemd.substack.com/p/neil-oliver-robert-malone-gb-news
IF there are only trace amounts of DNA plasmid remaining, perhaps Dr Offit could share with us the QC test results that show only trace amounts? And show us the studies that determine what a safe amount of contamination is?
Because the EMA didn’t seem very happy with the levels of contamination. Though it didn’t stop them letting governments everywhere inject people (despite the documented “you must do better” request) because they’re next to useless.