Did the United States Support Gain-of-Function Research in a Wuhan Laboratory?

Yes. But overwhelming evidence shows that SARS-CoV-2 was an animal-to-human spillover event.

On February 13, 2024, National Geographic published a book I wrote called, TELL ME WHEN IT’S OVER: AN INSIDER’S GUIDE TO DECIPHERING COVID MYTHS AND NAVIGATING OUR POST-PANDEMIC WORLD. For the past few months, I have been writing about various issues discussed in that book.

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In the wake of some emails that recently came to light, the question of whether the United States government knowingly funded gain-of-function research at the Wuhan Institute of Virology has resurfaced. Does this new information prove the lab-leak theory?

First, what is “gain-of-function” research? Second, did gain-of-function research give birth to SARS-CoV-2 virus? One way to understand gain-of-function research is through the prism of rabies virus. People get rabies when they are bitten by a rabid animal. Once under the skin, the virus travels up the nerves and enters the brain, where it causes delirium, seizures, coma, and invariably death. Rabies is without question the deadliest infection of humans.

Now, imagine that a scientist engineers rabies virus so that, instead of being transmitted by animal bites, it is transmitted by small droplets from the nose and mouth, like the common cold. This new virus would be highly contagious and uniformly fatal. In the absence of an effective vaccine, it could eliminate humans from the face of the earth. The good news is that no one has tried to make rabies virus more contagious. But that doesn’t mean that it’s not possible or that no one would be willing to try. Indeed, in 2011, one experiment so frightened U.S. public health officials that within two years federal regulators made gain-of-function research illegal.

The worrisome experiment took place at the University of Wisconsin, Madison. Researchers took a strain of influenza virus found in birds and altered it to grow in ferrets (which, like humans, are mammals). In other words, these researchers had taken a strain of influenza virus that was limited to birds—to which no one in the world had immunity—and altered it so that it might cause disease in people. They had created a potential pandemic virus.

In 2016, three years before SARS-CoV-2 virus entered the human population, the lead researcher studying coronaviruses at the Wuhan Institute of Virology was Dr. Zheng-Li Shi. Her studies were funded in part by the United States government through EcoHealth. Dr. Shi was studying a coronavirus strain called WIV1 (Wuhan Institute of Virology-1): a bat coronavirus that could grow in monkey cells in the laboratory but didn’t cause disease in people. The WIV1 strain bears no resemblance to SARS-CoV-2. Dr. Shi wanted to see what would happen if she combined WIV1 with each of eight different bat coronaviruses that had been found in caves in and around Wuhan. None of the combination viruses that she created, however, were more dangerous than the strain she had started with (WIV1). None of them, like WIV1, could cause disease in people. Although Dr. Shi had performed gain-of-function studies that would have been illegal in the United States, she didn’t create a coronavirus strain that was dangerous to people.

So, while it was true that the United States government funded gain-of-function research at the Wuhan Institute of Virology, no function was gained. The recent seemingly endless posting of hidden emails and secret communications by government officials—all breathlessly claiming conspiracy and coverup—has, in the final analysis, been much to do about nothing.

Indeed, overwhelming evidence continues to support an animal-to-human spillover event that occurred in the western section of the Huanan Wholesale Seafood Market at the end of 2019. This is consistent with many other animal-to-human spillover events in history. Influenza virus (birds), human immunodeficiency virus (chimps), Ebola virus (bats), mpox (rodents), and the coronaviruses SARS-1 (bats) and MERS (bats) were all originally animal viruses. Indeed, about 60 percent of human viruses and bacteria have their origins in animals.

For a lengthy but complete discussion about why it is now clear that SARS-CoV-2 was an animal-to-human spillover event, you might want to check out a podcast called Decoding the Gurus, which features evolutionary biologists Michael Worobey, Kristian Anderson, and Eddie Holmes.